Accession Number : ADB125245

Title :   Drug Development Against Parasitic Diseases: Synthesis of the Antimalarial Agent Qinghaosu and Analogs.

Descriptive Note : Annual rept. 15 Oct 86-14 Oct 87,

Corporate Author : SRI INTERNATIONAL MENLO PARK CA

Personal Author(s) : Avery, Mitchell A.

Report Date : 15 JAN 1988

Pagination or Media Count : 29

Abstract : A stereoselective total synthesis of (+)-artemisinin has been improved from 18 steps to 13 steps with a resultant 12-fold increase in the overall yield. A new class of tricyclic analogs of artemisinin has been discovered that possess good in vitro antimalarial activity. U.S. and foreign patents have been filed. One paper has been published and three others are in preparation. Keywords: Qinghaosu. (AW

Descriptors :   *ANTIMALARIALS, DRUGS, IN VITRO ANALYSIS, PARASITIC DISEASES, SYNTHESIS(CHEMISTRY), CHEMICAL ANALOGS, CYCLIC COMPOUNDS.

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE