Accession Number : ADB128713

Title :   Drug Development Against Parasitic Diseases: Synthesis of the Antimalarial Agent Qinghaosu and Analogs.

Descriptive Note : Annual rept.,

Corporate Author : SRI INTERNATIONAL MENLO PARK CA

Personal Author(s) : Avery, Mitchell A.

Report Date : 15 NOV 1986

Pagination or Media Count : 79

Abstract : New chemical methodology was proposed to carry out a stereoselective synthesis of the antimalarial agent Qinghaosu. Feasibility studies with model systems have demonstrated that the proposed methodology works. We have therefore undertaken and recently completed the stereoselective total synthesis of Qinghaosu beginning with commercially available R(+)-pulegone. This methodology has been extended to include the total synthesis of analogs of Qinghaosu. Keywords: Total synthesis of antimalarial drug, Qinghaosu, Total synthesis of analogs of Qinghaosu RA1; Antiparasitic. (KT)

Descriptors :   *ANTIMALARIALS, *SYNTHESIS(CHEMISTRY), CHEMICAL ANALOGS, CHEMICAL ANALYSIS, DRUGS, FEASIBILITY STUDIES, MODELS, PARASITIC DISEASES.

Subject Categories : Pharmacology
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE