Accession Number : ADB130072

Title :   Clinical Pharmacology Studies. Phase 1.

Descriptive Note : Annual rept.,

Corporate Author : JOHNS HOPKINS UNIV BALTIMORE MD DIV OF CLINICAL PHARMACOLOGY

Personal Author(s) : Lietman, Paul S. ; Petty, Brent G. ; Kornhauser, David M.

Report Date : 17 OCT 1988

Pagination or Media Count : 19

Abstract : The scientific work of this year centered around (1) The pharmacokinetics and pharmacodynamics of a low dose eight-hour intravenous infusion of pyridostigmine and (2) The bioava, safety, tolerance, pharmacokinetics and pharmacodynamics of two sustained release formulations of pyridostigmine compared to pyridostigmine syrup. The clinical portion of these two studies were designed in the second year under the provisions of Task Order 6. These protocols have been approved by the Johns Hopkins institutional review board and submitted for review by the Human Subjects Research Review Board. We anticipate that they will be initiated early in the third year of the contract. (kt)

Descriptors :   *PHARMACOKINETICS, *CHOLINESTERASE INHIBITORS, CLINICAL MEDICINE, FORMULATIONS, PHARMACOLOGY, RELEASE, PARENTERAL INFUSIONS.

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE