Accession Number : ADB132155

Title :   Synthesis Laboratory for the U.S. Army Medical Research Institute of Infectious Diseases Selection Panel.

Descriptive Note : Annual progress. rept. 1 Dec 87-30 Nov 88,

Corporate Author : SOUTHERN RESEARCH INST BIRMINGHAM AL

Personal Author(s) : Secrist, John A., III ; Kwong, Cecil D. ; Krauth, Charles A. ; Ford, Angela G. ; Jois, Yajnanarayana H.

Report Date : 13 FEB 1989

Pagination or Media Count : 86

Abstract : A synthesis laboratory has been established for the preparation of compounds to be evaluated against viruses of interest to U.S. Army medical Research Institute of Infectious Diseases. The synthesis of known compounds as well as new compounds has been under taken, and all compounds are being made in sufficient quantity to allow for full evaluation. Among the compounds prepared thus far are 1-benzyloxyadenosines, 9-substituted 1-benzyloxyadenines, 1,2,4,5,3,6-tetraazadiphosphorines, substituted imidazoles, selanadiazoles, triazoles, triazolotriazoles, guanidines, pyrazoles, adamantane derivatives, chloroquines, N-aminonucleosides, allopurinol acyclonuclosides, nucleotides of ribavirin and tiazofurin, and various other heterocyclic compounds. Keywords: Antiviral agents; Synthesis (Chemistry); Organic chemistry. (kt)

Descriptors :   *ANTIVIRAL AGENTS, *MEDICAL RESEARCH, ARMY RESEARCH, CHEMISTRY, GUANIDINES, HETEROCYCLIC COMPOUNDS, IMIDAZOLES, INFECTIOUS DISEASES, LABORATORIES, ORGANIC CHEMISTRY, PANELS, PREPARATION, PYRAZOLES, SELECTION, SUBSTITUTES, SYNTHESIS, TEST AND EVALUATION, VIRUSES.

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE