Accession Number : ADB132698
Title : Synthesis of Nucleoside Mono- and Dialdehydes as Antiviral Agents.
Descriptive Note : Annual rept. 15 Nov 87-14 Nov 88,
Corporate Author : ROCHESTER INST OF TECH NY
Personal Author(s) : Neenan, John P.
Report Date : 25 JAN 1989
Pagination or Media Count : 16
Abstract : Seven compounds were submitted for screening as potential antivirals during the reporting period: adenosine-2'-monoaldehyde (AVS number 4526); 5'-deoxyadenosine-2',3'-dialdehyde (AVS number 1214); 5-iodouridine-2-3'-dialdehyde (AVS number 1217);purine riboside-2'3'-dialdehyde (AVS number 5053); 5-iodouridine-2'-monoaldehyde (AVS number 5052); adenosine-3-monozlcdhyde (AVS) number 5219); and 5'-amino-5'-deoxyadenosine (AVS number 5220). The most notable achievement was the synthesis of adenosine-3'-monoaldehyde by: selectively blocking the 3'-aldehyde group of adenosine-2',3--dialdehyde with N,N'-diphenylethylenediamine; reduction of the intermediate 1,3-diphenylimidazolidine derivative with sodium borohydride; and deblocking the resultant adenosine-2'-hydroxy-3'-(1,3-diphenyl)-2-imidazolidine with p-toluenesulfonic acid.
Descriptors : *ALDEHYDES, *ANTIVIRAL AGENTS, *NUCLEOSIDES, SODIUM BOROHYDRIDES, SYNTHESIS(CHEMISTRY), ADENOSINE, ETHYLENEDIAMINE, IMIDAZOLES, TOLUENES, SULFONIC ACIDS.
Subject Categories : Pharmacology
Distribution Statement : APPROVED FOR PUBLIC RELEASE