Accession Number : ADB136918

Title :   Drug Development against Parasitic Diseases: Synthesis of the Antimalarial Agent Qinghaosu and Analogs.

Descriptive Note : Final rept.,

Corporate Author : SRI INTERNATIONAL MENLO PARK CA

Personal Author(s) : Avery, Mitchell A.

Report Date : 15 JAN 1988

Pagination or Media Count : 148

Abstract : Major accomplishments under this contract include an optimized, stereoselective, total synthesis of (+)-artemisinin (qinghaosu); the synthesis of several analogs of qinghaosu that possess good in vitro antimalarial activity; publication of one paper; filing of four patents; and compilation of data sufficient to warrant the preparation of four manuscripts for publication. Keywords: Total synthesis of antimalarial drug; Qinghaosu; Artemisinin; Total synthesis of analogs of Qinghaosu; RA 1. (KT)

Descriptors :   *ANTIPARASITIC DRUGS, ANALOGS, ANTIMALARIALS, DRUGS, IN VITRO ANALYSIS, PARASITIC DISEASES, PATENTS, PREPARATION, SYNTHESIS, CHEMICAL ANALOGS.

Subject Categories : Pharmacology
      Industrial Chemistry and Chemical Processing

Distribution Statement : APPROVED FOR PUBLIC RELEASE