Accession Number : ADB137248

Title :   Testing of Experimental Compounds for Efficacy against Leishmania.

Descriptive Note : Annual rept. 1 Jan-31 Dec 88,

Corporate Author : GEORGIA UNIV RESEARCH FOUNDATION INC ATHENS

Personal Author(s) : Hanson, William L. ; Waits, Virginia B. ; Chapman, Willie L., Jr

Report Date : 28 FEB 1989

Pagination or Media Count : 37

Abstract : A total of 683 compounds of diverse chemical classes including inosine analogs and analogs of WR06026 were studied in the primary visceral test system for suppressive activity against Leishmania donovani in golden hamsters. A total of 16 of these were active. The 8-aminoquinolines were the most potent of the active compounds but all but one was toxic to the host. The active compounds included some inosine analogs and some analogs of WR06026. The activity of most of these was low and some of the inosine analogs were toxic. The antileishmanial efficacy of WR06026 when administered in a single injection 3 days prior to infection with Leishmania donovani suggests that metabolites of this compound are active and that these active metabolites are relatively long-lived. Keywords: Antileishmanials; Antileishmanial agents; Leishmania donovani; Chemotherapy; Golden hamster; WR06026; Metabolites; In vivo tests; RA 1. (KT)

Descriptors :   *PARASITIC DISEASES, *ANTIPARASITIC DRUGS, *INOSINE, *LEISHMANIA, *QUINOLINES, ANALOGS, CHEMOTHERAPY, HAMSTERS, IN VIVO ANALYSIS, INFECTIOUS DISEASES, METABOLITES, ORGANS(ANATOMY), SUPPRESSION, TEST AND EVALUATION, TEST METHODS, TOXICITY.

Subject Categories : Pharmacology
      Microbiology
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE