Accession Number : ADB138843

Title :   Development of Systems for Delivery of Antiviral Drugs.

Descriptive Note : Annual rept. 30 Sep 87-29 Sep 88,

Corporate Author : SOUTHERN RESEARCH INST BIRMINGHAM AL

Personal Author(s) : Shannon, William M. ; Secrist, John A., III ; Hollingshead, Melinda G.

Report Date : OCT 1988

Pagination or Media Count : 34

Abstract : Ribavirin, a broad-spectrum antiviral agent with potent activity in vitro against a number of important RNA viruses of military significance, is severely limited in its usefulness against virus-induced encephalitic diseases because it does not cross the blood-brain barrier will enough to achieve effective antiviral concentrations in the brain. Our efforts are directed toward the brain-specific delivery of ribavirin and other antiviral agents by means of a redox prodrug concept. The scope of the research program involves the synthesis of CNS-targeted prodrug esters of ribavirin and selenazole, pharmacokinetic studies of drug distribution and sustained delivery of drug in the brain, and the evaluation of the therapeutic efficacy of these antiviral prodrugs compared with the parent drugs in the treatment of lethal Venezuelan equine encephalitis (VEE), virus and Japanese encephalitis (JE) virus infections in mice. Antiviral drugs; Ribavirin; Japanese encephalitis; Prodrug esters; Brain-specific drug targeting; Drug delivery; RA 1. (KT)

Descriptors :   *ANTIVIRAL AGENTS, *DELIVERY, *DRUGS, BARRIERS, BLOOD, BRAIN, BROADBAND, DISTRIBUTION, ESTERS, IN VITRO ANALYSIS, JAPANESE ENCEPHALITIS, LETHALITY, MICE, PHARMACOKINETICS, POTENCY, RIBONUCLEIC ACIDS, SPECTRA, THERAPY, VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS, VIRUS DISEASES, VIRUSES.

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE