Accession Number : ADB142364

Title :   Synthesis Laboratory for the U.S. Army Medical Research Institute of Infectious Diseases Selection Panel.

Descriptive Note : Annual progress. rept. no. 17, 1 Dec 88-30 Nov 89,

Corporate Author : SOUTHERN RESEARCH INST BIRMINGHAM AL

Personal Author(s) : Secrist, John A., III ; Kwong, Cecil D. ; Krauth, Charles A. ; Ford, Angela G. ; Jois, Yajnanarayana H.

Report Date : 05 FEB 1990

Pagination or Media Count : 50

Abstract : A synthesis laboratory has been established for the preparation of compounds to be evaluated against viruses of interest to U.S. Army Medical Research Institute of Infectious Diseases. The synthesis of known compounds as well as new compounds has been undertaken, and all compounds are being made in sufficient quantity to allow for full evaluation. Among the compounds prepared thus far are 1-benzyl-benyloxadenines, 1,2,4,5,3,6- tetraazadiphosphorines, substituted imidazoles, selenadiazoles, triazoles, oxyadenosines, 9-substituted 1-benzyltriazoles, triazolotriazoles, guanidines, pyrazoles, adamantane derivatives, chloroquines, N1-aminonucleosides, allopurinol acyclonucleosides, nucleotides of ribavirin and tiazofurin, and various other heterocyclic compounds. Keywords: Antiviral agents. (kt)

Descriptors :   *ANTIVIRAL AGENTS, *SYNTHESIS(CHEMISTRY), ARMY RESEARCH, GUANIDINES, HETEROCYCLIC COMPOUNDS, IMIDAZOLES, INFECTIOUS DISEASES, LABORATORIES, ADENINE, PHOSPHORS, IMIDES, MEDICAL RESEARCH, PANELS, PREPARATION, PYRAZOLES, SELECTION, SUBSTITUTES, TEST AND EVALUATION, VIRUSES.

Subject Categories : Pharmacology
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE