Accession Number : ADB143272

Title :   Unique Purine Nucleosides with Broad-Spectrum RNA Antiviral Potential.

Descriptive Note : Final rept. 12 Jun 89-31 Jan 90,

Corporate Author : IOWA UNIV IOWA CITY

Personal Author(s) : Nair, Vasu

Report Date : 02 MAR 1990

Pagination or Media Count : 26

Abstract : This project is concerned with the biochemically-based rational design, synthesis, purification, complete spectral characterization, and antiviral evaluation of some unique adenine and hypoxanthine deoxynucleosides. A total of seven compounds were produced through complex multi-step syntheses and submitted for antiviral evaluation. The work at present is right on schedule and in complete accordance with the contract agreement. Based on previous results from our laboratory, information on the exotic ribonucleic acid viruses and their key enzymes, rational design, and the current status of antiviral research in this and related areas, this project has a very high probability of producing antivirally active compounds of relevance and importance to the drug development program of the USAMRDC. Deoxynucleosides, Synthesis, RNA Antiviral molecules, Drug synthesis, Antiviral drugs, Drug development, RNA viruses, Encephalitis, Army, Medical research. (jg)

Descriptors :   *ANTIVIRAL AGENTS, *NUCLEOSIDES, *PURINES, *RIBONUCLEIC ACIDS, ADENINE, AGREEMENTS, BROADBAND, CONTRACTS, DRUGS, ENCEPHALITIS, ENZYMES, MEDICAL RESEARCH, MOLECULES, PURIFICATION, SPECTRA, SYNTHESIS, TEST AND EVALUATION, VIRUSES.

Subject Categories : Biochemistry
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE