Accession Number : ADB144742

Title :   Synthesis of Improved Antileishmanial and Antitrypanosomal Drugs Treatment and Prophylaxis.

Descriptive Note : Annual rept.,

Corporate Author : ASH STEVENS INC DETROIT MI

Personal Author(s) : Markovac, A. ; Dagli, D. J. ; Ash, A. B. ; Stevens, C. L.

Report Date : MAR 1989

Pagination or Media Count : 61

Abstract : During the current reporting period this program was directed at the preparation of improved antileishmanial drugs based on the identification of two metabolites of the highly-active antileishmanial drug 8-(6-diethylaminohexylamino)-6-methoxy-4-methlquinoline, WR 6026. Ten compounds were synthesized and limited test data against visceral leishmaniasis in the hamster is reported. The first metabolite was the 4-hydroxymethyl derivative of WR 6026. The second metabolite was the 8-(6-ethylaminohexyl)amino derivative of WR 6026. Ten analogs of these metabolites of WR 6026 were prepared during the reporting period. Keywords: Antileishmanials, Metabolites, Diethylaminohexylamino methylquinoline. (JES)

Descriptors :   *ANTIBIOTICS, *LEISHMANIASIS, *SYNTHESIS(CHEMISTRY), EXPERIMENTAL DATA, LEISHMANIA, METABOLITES, ORGANS(ANATOMY), PREVENTIVE MEDICINE.

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE