Accession Number : ADB146426

Title :   Development of Methods for Carrier-Mediated Targeted Delivery of Antiviral Compounds Using Monoclonal Antibodies.

Descriptive Note : Annual rept. 1 Apr 88-31 Mar 89,

Corporate Author : SRI INTERNATIONAL MENLO PARK CA

Personal Author(s) : Dawson, Marcia I. ; Sidwell, Robert W. ; Barnett, Bill B.

Report Date : 01 APR 1989

Pagination or Media Count : 153

Abstract : SRI International and Utah State University are developing methodology to assess the effectiveness of antiviral drug-monoclonal antibody conjugate therapy for the treatment of viral infections. Specifically, monoclonal antibodies to Pinchinde virus surface antigens were prepared and conjugated to the antiviral drug ribavirin, and the resulting conjugates will be screened for antiviral activity both in vitro and in animal model systems. Keywords: Synthesis and biological evaluation of antiviral drug (ribavirin)-monoclonal antibody conjugates for treatment of Pichinde virus infections. (JES)

Descriptors :   *ANTIBODIES, ANIMALS, ANTIGENS, ANTIVIRAL AGENTS, BIOLOGY, CLONES, DRUGS, IN VITRO ANALYSIS, INFECTIOUS DISEASES, MEDICAL SERVICES, METHODOLOGY, MODELS, MONOCLONAL ANTIBODIES, SURFACES, SYNTHESIS, TEST AND EVALUATION, VIRUS DISEASES, VIRUSES.

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE