Accession Number : ADB147017

Title :   Influence of Organophosphate and Anticholinergic Agents on CA++ -Dependent Processes in Synaptic Transmission.

Descriptive Note : Final rept. 15 Sep 81-14 Dec 83,

Corporate Author : TEXAS UNIV HEALTH SCIENCE CENTER AT SAN ANTONIO DEPT OF PHARMACOLOGY

Personal Author(s) : Ross, David H.

Report Date : 12 JUN 1989

Pagination or Media Count : 69

Abstract : The present report reviews progress over a period of 28 months in studies concerning the effects of organophosphates and anticholinergic agents on Ca++ -dependent processes in synaptic transmission. Processes which were studied include voltage-dependent and receptor operated Ca++ channels, Na+/Ca++ exchange, Ca++/Mg++ -ATPase plasma membrane pump, and ATP-dependent Ca++ uptake into endoplasmic reticulum. Initial studies focused on the effect of muscarinic receptor agonists on voltage-dependent Ca++ channels, Ca++/Mg++ -ATPase, ATP-dependent Ca++ uptake, and Na/Ca++ exchange in rat brain synaptosomes and synaptosomal membranes. These studies characterized two phases of Ca++ influx and time courses for Ca++ entry. Acute in vitro soman treatment (50 microns for 2 min) did not alter Ca++ influx through voltage-operated channels. Keywords: Acetylcholine; Organophosphates; Calcium transport; Synaptosome; Pharmacology. (JES)

Descriptors :   *PARASYMPATHOLYTIC AGENTS, ACETYLCHOLINE, CALCIUM, MEMBRANES, MUSCARINE, ORGANOPHOSPHATES, PHARMACOLOGY, PLASMAS(PHYSICS), PUMPS, RECEPTION, SYNAPSE, TRANSMITTANCE, TRANSPORT.

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE