Accession Number : ADB147447

Title :   Testing Compounds for Efficacy against Schistosomiasis.

Descriptive Note : Final rept. 15 Aug 85-14 Aug 89,

Corporate Author : LOWELL UNIV MA CENTER FOR TROPICAL DISEASES

Personal Author(s) : Bruce, John I.

Report Date : 19 JAN 1990

Pagination or Media Count : 119

Abstract : During this four year funding period, attempts were made to determine the efficacy of the compound Niclosamide as a potential Topical Antipenetrant (TAP) against cercariae (ineffective larval) of Schistosoma mansoni, S. haemotobium, and S.japonicum in monkey, hamster and mouse animal test models; to assess the potential for TAP to interact with new insect repellent when applied simultaneously to skin; determine the oral prophylactic activity of 28 candidate compounds against S. mansoni, S. haematobium and S. japonicum in monkey, hamster and mouse test models; to determine if the marmoset monkey can be employed as a model to study schistosome cercarial penetration dynamics and to provide drug-resistant schistosome strains for drug-tests when warranted. Keywords: Schistosomiasis, S. mansoni, S. haematobium, S. japonicum, Niclosamide, Prophylactic, Antischistosomal drug, Cercariae, Antipenetrant, Repellant, Cebus apella, Brazil, Kenya, Hamster, Mouse, Monkey, Mesoricetus auratus, Mus musculus, Toxicity, Dermal Toxicity, RAI.

Descriptors :   *ANTISCHISTOSOMAL DRUGS, *PREVENTIVE MEDICINE, ANIMALS, BRAZIL, CERCARIAE, INSECT REPELLENTS, KENYA, MICE, MODELS, MONKEYS, ORAL INTAKE, SCHISTOSOMA MANSONI, SCHISTOSOMIASIS, SKIN(ANATOMY), TOXICITY.

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE