Accession Number : ADB148116

Title :   Synthesis of Phosphates and Phosphonates of 1',2'-Seco=Nucleosides and Other Antivirals.

Descriptive Note : Final rept. 12 Jun 89-31 Jan 90,

Corporate Author : RHODE ISLAND UNIV KINGSTON

Personal Author(s) : Abushanab, Elie

Report Date : 02 MAR 1990

Pagination or Media Count : 12

Abstract : Synthetic methodologies for the preparation of nucleoside phosphates and phosphonates have been developed. Phosphates as well as cyclic phosphates have been synthesized. A unique reaction was discovered that allows the preparation of phosphonate chirons. The latter have been successfully converted to 1', 2-seco-nucleoside phosphonates and homophosphonates. Keywords: Drug synthesis; Antiviral drugs; Drug development; Acyclic; Chiral; Nucleosides; Phosphates; Phosphonates medicine. (js)

Descriptors :   *ANTIVIRAL AGENTS, *MEDICINE, CYCLES, DRUGS, METHODOLOGY, NUCLEOSIDES, PHOSPHATES, PHOSPHONATES, PREPARATION, SYNTHESIS.

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE