Accession Number : ADB148205

Title :   Research in Drug Development against Viral Diseases of Military Importance (Biological Testing).

Descriptive Note : Annual rept.15 Nov 87-4 Nov 88,

Corporate Author : SOUTHERN RESEARCH INST BIRMINGHAM AL

Personal Author(s) : Shannon, W. M. ; Arnett, G. ; Brazier, A. D. ; Dulmadge, E. A. ; Hollingshead, M. G.

Report Date : 15 DEC 1988

Pagination or Media Count : 404

Abstract : The purpose of this program is to evaluate the efficacy of candidate antiviral compounds against a spectrum of viruses of military importance. This program involves (a) primary testing of chemical compounds and natural products for antiviral efficacy in vitro using CPE-inhibition and plaque-reduction assays, (b) primary testing of compounds for antiviral efficacy in vivo in animal model systems, and (c) secondary evaluation of the active candidate antiviral compounds. The target viruses for in vitro testing are Vaccinia Virus (VV), Adenovirus (AD2), Vesicular Stomatitis Virus (VSV), Punta Toro Virus (PT), Sandfly Fever Virus (SF), Yellow Fever Virus (YF), Venezuelan Equine Encephalomyelitis Virus (VEE), Japanese Encephalitis Virus (JE), Pichinde Virus (PIC), and Hantaan Virus (HTN). The current in vivo systems are Pichinde Virus infection of hamsters, Venezuelan Equine Encephalomyelitis Virus, Japanese Encephalitis Virus and Vaccinia Virus infections of mice. Over 2600 compounds have been received for in vitro evaluation and over 14,000 assays have been performed on this contract to date. Compounds have been identified in nearly all virus systems that have confirmed antiviral activity exceeding that of the various positive control compounds (Ribavirin, Selenazole, and Ara-A). Many of these compounds represent potent and selective new antiviral agents. (jes)

Descriptors :   *VIRUS DISEASES, *YELLOW FEVER VIRUS, ADENOVIRUSES, ANIMALS, ANTIVIRAL AGENTS, BIOLOGY, CHEMICAL COMPOUNDS, CONTROL, DRUGS, EFFICIENCY, HAMSTERS, HANTAAN VIRUS, IN VITRO ANALYSIS, IN VIVO ANALYSIS, JAPANESE ENCEPHALITIS VIRUSES, MICE, MODELS, NATURAL RESOURCES, SANDFLY FEVER VIRUS INFECTION, SECONDARY, SPECTRA, TARGETS, TEST AND EVALUATION, VACCINIA VIRUS, VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS, VESICULAR STOMATITIS, VIRUSES.

Subject Categories : Pharmacology
      Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE