Accession Number : ADB148208

Title :   Research in Drug Development against Viral Diseases of Military Importance (Biological Testing).

Descriptive Note : Annual rept. 15 Nov 88-14 Nov 89,

Corporate Author : SOUTHERN RESEARCH INST BIRMINGHAM AL

Personal Author(s) : Shannon, W. M. ; Arnett, G. ; Brazier, A. D. ; Dulmadge, E. A. ; Hollingshead, M. G.

Report Date : 15 DEC 1989

Pagination or Media Count : 432

Abstract : The purpose of this program is to evaluate the efficacy of candidate antiviral compounds against a spectrum of viruses of military importance. This program involves (a) primary testing of chemical compounds and natural products for antiviral efficacy in vitro using CPE-inhibition, plaque-reduction, and MTT assays, (b) primary testing of compounds for antiviral efficacy in vivo in animal model systems, and (c) secondary evaluation of the active candidate antiviral compounds. The target viruses for in vitro testing are Vaccinia Virus (VV), Adenovirus (AD2), Vesicular Stomatitis Virus (VSV), Punta Toro Virus (PT), Sandfly Fever Virus (SF), Yellow Fever Virus (YF), Venezuelan Equine Encephalomyelitis Virus (VE), Japanese Encephalitis Virus (JE), Pichinde Virus (PIC), and Hantaan VIrus (HTN). The current in vivo systems are Pichinde Virus infection of hamsters, Venezuelan Equine Encephalomyelitis Virus, Japanese Encephalitis Virus and Vaccinia Virus infections of mice. (js)

Descriptors :   *ANTIVIRAL AGENTS, ADENOVIRUSES, ANIMALS, BIOLOGY, CHEMICAL COMPOUNDS, DRUGS, EFFICIENCY, HAMSTERS, HANTAAN VIRUS, IN VITRO ANALYSIS, IN VIVO ANALYSIS, JAPANESE ENCEPHALITIS VIRUSES, MICE, MODELS, NATURAL RESOURCES, SANDFLY FEVER VIRUS INFECTION, SECONDARY, SPECTRA, TARGETS, TEST AND EVALUATION, VACCINIA VIRUS, VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS, VESICULAR STOMATITIS, VIRUS DISEASES, VIRUSES, YELLOW FEVER VIRUS.

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE