Accession Number : ADB148458

Title :   Development of Methods for Carrier-Mediated Targeted Delivery of Antiviral Compounds Using Monoclonal Antibodies.

Descriptive Note : Final rept.,

Corporate Author : SRI INTERNATIONAL MENLO PARK CA

Personal Author(s) : Dawson, Marcia I. ; Sidwell, Robert W. ; Barnett, Bill B.

Report Date : 01 JAN 1990

Pagination or Media Count : 237

Abstract : SRI International and Utah State University developed methodology to assess the effectiveness of antiviral drug monoclonal antibody conjugate therapy for the treatment of viral infections. Specifically, monoclonal antibodies to Pichinde virus surface antigens were prepared and conjugated to the antiviral drug ribavirin, and the resulting conjugates were screened for antiviral activity in vitro. Immunoconjugates were inactive because the monoclonal antibody did not internalize. Subsequent work using a polyclonal antibody produced an immunotoxin that had antiviral activity. Animal model systems were developed for in vivo evaluations. (js)

Descriptors :   *ANTIVIRAL AGENTS, *MONOCLONAL ANTIBODIES, ANIMALS, ANTIGENS, IN VITRO ANALYSIS, IN VIVO ANALYSIS, INFECTIOUS DISEASES, MEDICAL SERVICES, MODELS, SURFACES, TEST AND EVALUATION, VIRUS DISEASES, VIRUSES.

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE