Accession Number : ADB151023

Title :   Chemotherapy of Rodent Malaria.

Descriptive Note : Annual rept. 16 Oct 88-15 Oct 89,

Corporate Author : LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE (UNITED KINGDOM)

Personal Author(s) : Peters, Wallace

Report Date : 16 OCT 1989

Pagination or Media Count : 262

Abstract : Data from in vivo blood schizontocidal activity tests rodent malaria with WR 149244, WR 256473, WR 93133, WR 242511, WR 238605 and Loratadine are presented. The final results from the continuing study on cross-resistance and first data from a series of experiments examining the influence of a range of WRAIR compounds, as well as some antihistaminic drugs, in combination with chloroquine, mefloquine, halofantrine or artemisinin on resistance to these primary antimalarials in appropriate strains of Plasmodium yoelii are also included. Studies on gametocytocidal activity of four metabolites of primaquine and four Cinchona alkaloids are described. Two floxacrine analogs (WR 243251 and WR 250547), and two 8-aminoquinolines (WR 199508 and WR 238605), a tetrahydrofuran (WR 93133), and two antibiotics (spiramycin and lincomycin) are examined for causal prophylactic activity against P.y.nigeriensis.

Descriptors :   *CHEMOTHERAPY, ANTIBIOTICS, ANTIMALARIALS, CHLOROQUINE, CYTOLOGY, FURANS, HYDROXYL RADICALS, MALARIA, METABOLITES, PRIMAQUINE, RODENTS.

Subject Categories : Microbiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE