Accession Number : ADB152958

Title :   Synthesis of Antidotes for Organophosphorus Acetylcholinesterase Inhibitors.

Descriptive Note : Annual rept. 1 Jan-31 Dec 90,

Corporate Author : VIRGINIA UNIV CHARLOTTESVILLE

Personal Author(s) : Sundberg, Richard J.

Report Date : 23 JAN 1991

Pagination or Media Count : 38

Abstract : This report describes the preparation of heteroaromatic carbamates for evaluation of prophylactic and antidotal activity against organophosphorus (OP) acetylcholinesterase inhibitors. Synthetic procedures for 27 new compounds are included. Both in vitro acetycholinesterase activity and in vivo prophylactic and antidotal activity against OP toxicity is reported for several of the compounds prepared earlier in the project. Tentative structure activity relationships are considered.

Descriptors :   ANTIDOTES, AROMATIC COMPOUNDS, CARBAMATES, CHOLINESTERASE INHIBITORS, HETEROCYCLIC COMPOUNDS, IN VITRO ANALYSIS, ORGANIC PHOSPHORUS COMPOUNDS, PREPARATION, PREVENTIVE MEDICINE, SYNTHESIS, TOXICITY.

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE