Accession Number : ADB154233

Title :   Feasibility of a Subunit Vaccine for Hepatitis A Virus.

Descriptive Note : Midterm rept. 23 May 88-1 Jan 91,

Corporate Author : UTAH UNIV SALT LAKE CITY

Personal Author(s) : Ehrenfeld, Elvera

Report Date : 07 JAN 1991

Pagination or Media Count : 22

Abstract : The overall goals of this contrast are to explore the feasibility of the development of subunit vaccine for hepatitis A virus (HAV). We have produced HAV structural proteins by recombinant DNA technology and characterized tham as antigens for the induction of protective immunity. We have analyzed the replication strategies of HAV which contribute to its distinguishing growth properties and we have identified the HAV protein 3C as a viral protease. We have evaluated the human response to HAV infection.

Descriptors :   , ANTIGENS, DEOXYRIBONUCLEIC ACIDS, FEASIBILITY STUDIES, GENETIC ENGINEERING, GROWTH(GENERAL), HEPATITIS, HUMANS, IMMUNITY, INFECTIOUS DISEASES, MOLECULAR STRUCTURE, PEPTIDE HYDROLASES, PROTEINS, RESPONSE, VACCINES, VIRUSES.

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE