Accession Number : ADB155642

Title :   Determination of the In vitro and In vivo Activity of Compounds Tested against Punta Toro Virus.

Descriptive Note : Annual rept. 1 Dec 89-30 Dec 90,

Corporate Author : UTAH STATE UNIV LOGAN

Personal Author(s) : Sidwell, Robert W.

Report Date : 28 DEC 1990

Pagination or Media Count : 237

Abstract : Approximate LD50 values were obtained in 3-4 week-old C57BL/6 mice or 4-5 week-old Swiss Webster mice for 37 AVS compounds. Effect of AVS Compounds on Hepatotropic Infections in Mice Induced by the Adames Strain of Punta Toro Virus: A total of 64 anti-PTV experiments were run with 25 AVS compounds using the Adames strain of PTV. Promising compounds included AVS65, 79, 111, 272 347, 1761, 1968, 2276, 2285, 2812, and 5311. Effect of AVS Compounds on Intracerebral Infections in Mice Induced by the Balliet Strain of Punta Toro Virus: A total of 16 AVS compounds were evaluated against the CNS infection induced by the Balliet strain of PTV. Compounds AVS6080 and 6082 were considered moderately effective. Comparison of the Effects of AVS01, AVS02, and AVS06 on Daily Disease Parameters in Punta Toro Virus-Infected Mice: A single p.o. treatment given 24 hr post-virus inoculation with LD50/16 dosages of AVS01, 02, or 206 prevented the PTV-associated death of the mice and significantly lowered the already developing viral titers in the blood and all tissues. In this experiment, AVS01 was least effective in keeping the virus below detectable limits. AVS206 was consistently most effective.

Descriptors :   *VIRUS DISEASES, *MEDICAL RESEARCH, HEPATITIS VIRUSES, ANTIVIRAL AGENTS, VIRUSES, BLOOD, CENTRAL NERVOUS SYSTEM, CEREBRAL CORTEX, DAILY OCCURRENCE, DISEASES, IN VITRO ANALYSIS, IN VIVO ANALYSIS, INFECTIOUS DISEASES, MICE, PARAMETERS, TISSUES(BIOLOGY).

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE