Accession Number : ADB156768

Title :   Anticholinesterase Therapeutics.

Descriptive Note : Midterm rept. 14 Feb 90-13 Feb 91,

Corporate Author : SRI INTERNATIONAL MENLO PARK CA

Personal Author(s) : Harris, R. N., III ; Koolpe, G. A. ; Sanderson, R. A. ; Peterson, G. A.

Report Date : 03 APR 1991

Pagination or Media Count : 45

Abstract : A total of 27 new experimental therapeutic agents for the treatment of anticholinesterase intoxication were prepared, characterized, and submitted to the Walter Reed Army Institute of Research. Most of the compounds are members of the quaternary 1,2,3-trisubstituted imidazolium ring system. The first precursor to a fused bicyclic, conformationally rigid analog of the imidazolium compounds was prepared in modest yield. Attempts to quaternize 1-methyl-2-(nitro)methylimidazole gave only products resulting from alkylation at the C-2 nitromethyl group. This result disclosed the zwitterionic nature of the 2-(nitro)methylimidazole system and thwarted attempts to prepare type C proposed targets.

Descriptors :   , ALKYLATION, ANALOG SYSTEMS, CHOLINESTERASE INHIBITORS, INTOXICATION, PRECURSORS, RIGIDITY, THERAPY.

Subject Categories : Chemical, Biological and Radiological Warfare

Distribution Statement : APPROVED FOR PUBLIC RELEASE