Accession Number : ADB157099

Title :   Synthesis of Potential Prophylactic Agents Against Cyanide Intoxication.

Descriptive Note : Annual rept. 9 Mar 90-8 Mar 91,

Corporate Author : SOUTHERN RESEARCH INST BIRMINGHAM AL

Personal Author(s) : Piper, James R.

Report Date : 19 JUN 1991

Pagination or Media Count : 53

Abstract : The goal of the proposed research is to identify through synthesis and testing compounds that may provide prophylaxis against cyanide intoxication. A review of the literature for both antidotes and prophylactic agents against cyanide has enabled us to conclude that better prophylaxis cyanide might be achieved from one or all of the following approaches. (1) Through the administration of sulfur-rich compounds such as polysulfide analogues of cysteine and similar compounds such as thioalkanoic acids, alkylthiols, and aminothiols which will act like cysteine to provide sulfur for sulfurtransferase reactions. (2) The use of compounds containing carbonyl groups. These compounds would be analogues of pyruvate and a -ketoglutarate and would bind directly to cyanide forming relatively stable and nontoxic cyanohydrins. (3) Exploring other compounds that can bind cyanide directly; of particular interest are two compound classes: (a) N-alkoxy heterocyclic compounds that react with cyanide ion to form covalent products and (b) structurally similar N-arylthio compounds which react with cyanide ion to give arylthiocyanates.

Descriptors :   ACIDS, AMINES, ANTIDOTES, CARBONYL COMPOUNDS, COVALENT BONDS, CYANIDES, CYSTEINE, INTOXICATION, IONS, PREVENTIVE MEDICINE, SULFUR, SYNTHESIS, THIOLS.

Subject Categories : Physical Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE