Accession Number : ADB157566

Title :   Synthesis Laboratory for the U.S. Army Medical Research Institute of Infectious Diseases Selection Panel.

Descriptive Note : Final rept. 1 Dec 85-28 Feb 91,

Corporate Author : SOUTHERN RESEARCH INST BIRMINGHAM AL

Personal Author(s) : Secrist, John A., III ; Kwong, Cecil D. ; Krauth, Charles A. ; Carter, Deborah A. ; Hanna, Lisa K.

Report Date : 26 JUN 1991

Pagination or Media Count : 213

Abstract : A synthesis laboratory has been established for the preparation of compounds to be evaluated against viruses of interest of U.S. Army Medical Research Institute of Infectious Diseases. The synthesis of known compounds as well as new compounds has been undertaken, and all compounds are being made in sufficient quantity to allow for full evaluation. Among the compounds prepared thus far are 1-benzyloxy-adenosines, 9-substituted 1-benzyloxyadenines, 1,2,4,5,3,6,-tetraazadiphosphorines, substituted imidazoles, selenadiazoles, triazoles, triazolotriazoles, guanidines, pyrazoles, adamantane derivatives, chloroquines, Ni-aminonucleosides, allopurinol acyclonucleosides, nucleotides of ribavirin and tiazofurin, and various other heterocyclic compounds.

Descriptors :   ADAMANTANES, ARMY RESEARCH, CHEMICAL DERIVATIVES, GUANIDINES, HETEROCYCLIC COMPOUNDS, IMIDAZOLES, INFECTIOUS DISEASES, LABORATORIES, MEDICAL RESEARCH, PANELS, PREPARATION, PYRAZOLES, SELECTION, SUBSTITUTES, SYNTHESIS, TEST AND EVALUATION, VIRUSES.

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE