Accession Number : ADB160612

Title :   Research in Drug Development against Viral Diseases of Military Importance (Biological Testing). Volume 2.

Descriptive Note : Final rept. 15 Nov 85-31 Jan 91,

Corporate Author : SOUTHERN RESEARCH INST BIRMINGHAM AL

Personal Author(s) : Shannon, W. M. ; Arnett, G. ; Brazier, A. D. ; Hollingshead, M. G. ; Kirsi, J. J.

Report Date : 01 MAR 1991

Pagination or Media Count : 600

Abstract : The purpose of this program is to evaluate the efficacy of candidate antiviral compounds against a spectrum of viruses of military importance. This program involves (a) primary testing of chemical compounds and natural products for antiviral efficacy in vitro using standard CPE-inhibition assays, (b) primary testing of compounds for antiviral efficacy in vivo in animal model systems, and (c) secondary evaluation of the active candidate antiviral compounds. The target viruses for in vitro testing are Vaccinia Virus (VV), Adenovirus (AD2), Vesicular Stomatitis Virus (VSV), Punta Toro Virus (PT), Sandfly fever Virus (SF), Yellow Fever Virus (YF), Venezuelan Equine Encephalomyelitis Virus (VE), Japanese Encephalitis Virus, Pichinde Virus (PIC), Hantaan Virus (HTN), and Human Immunodeficiency Virus (HIV). The in vivo systems are Pichinde Virus infection of hamsters, Venezuelan Equine Encephalomyelitis Virus, Japanese Encephalitis Virus and Vaccinia virus infections of mice. Approximately 10,000 compounds have been received for in vitro evaluation and over 66,000 assays have been performed on this contract. Compounds have been identified in nearly all virus systems that have confirmed antiviral activity equal or exceeding that of the various positive control compounds (Ribavirin, Selenazofurin, Carbocyclic-3-aza-adenosine, Adenosine dialdehyde, Ara-A, ddC and AZT). Many of these compounds represent potent and selective new antiviral agents.

Descriptors :   , ADENOVIRUSES, ANIMALS, ANTIVIRAL AGENTS, BIOLOGY, CHEMICAL COMPOUNDS, CONTROL, DRUGS, EFFICIENCY, HAMSTERS, HANTAAN VIRUS, HUMAN IMMUNODEFICIENCY VIRUSES, IN VITRO ANALYSIS, IN VIVO ANALYSIS, JAPANESE ENCEPHALITIS VIRUSES, MICE, MODELS, NATURAL RESOURCES, SANDFLY FEVER VIRUS INFECTION, SECONDARY, SPECTRA, TARGETS, TEST AND EVALUATION, VACCINIA VIRUS, VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS, VESICULAR STOMATITIS, VIRUS DISEASES, VIRUSES, YELLOW FEVER VIRUS.

Subject Categories : Microbiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE