Accession Number : ADB161297

Title :   Drug Development against Viral Diseases.

Descriptive Note : Annual rept. 1 Feb 89-31 Jan 90,

Corporate Author : YALE UNIV NEW HAVEN CT SCHOOL OF MEDICINE

Personal Author(s) : Tignor, Gregory H.

Report Date : 01 FEB 1990

Pagination or Media Count : 37

Abstract : Ninety-three drugs were tested against LCMV in the adult mouse model. Fourteen drugs gave VR scores greater than 1.2 which places these drugs in the top 90th percentile of all drugs tested in the LCMV model. The identity of the ribavirin resistant virus has been established by mouse neutralization test using acetone-ether extracted CCHF virus mouse polyclonal antibody. There were no breakthrough mice in the neutralization test. Ribavirin-resistant virus was re-isolated from liver tissue of infected mice.

Descriptors :   , ADULTS, ANATOMICAL MODELS, DRUGS, LIVER, MICE, NEUTRALIZATION, TEST AND EVALUATION, TISSUES(BIOLOGY), VIRUS DISEASES.

Subject Categories : Microbiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE