Accession Number : ADB163607

Title :   Prolonged Preservation of Human Platelets for Combat Casualty Care.

Descriptive Note : Final rept. 15 Jul 91-15 Jan 92,

Corporate Author : LIFECELL CORP THE WOODLANDS TX

Personal Author(s) : Livesey, Stephen A.

Report Date : 15 JAN 1992

Pagination or Media Count : 48

Abstract : The aim of this Phase I proposal was to develop protocols for extending shelf-life of platelets with 220C and 4 deg C storage and following cryopreservation. To achieve this aim, we have combined cryopreservation protocols with specific biochemical manipulations of the multicomponent signal transduction mechanisms present in platelets. This approach is designed to maintain both the numerical and functional recovery of platelets following storage. Platelet preservation, Stimulus response, RAII, SBIRm Second messengers, Cryopreservation.

Descriptors :   *PRESERVATION, *SHELF LIFE, *STORAGE, *BLOOD PLATELETS, RECOVERY, BIOCHEMISTRY.

Subject Categories : Biochemistry
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE