Accession Number : ADB165436

Title :   Drug Development Against Viral Diseases of Military Importance (Directed Synthesis).

Descriptive Note : Final rept. 1 Mar-31 Dec 91,

Corporate Author : SOUTHERN RESEARCH INST BIRMINGHAM AL

Personal Author(s) : Secrist, John A., III ; Kwong, Cecil D. ; Krauth, Charles A. ; Carter, Deborah A. ; Hanna, Lisa K.

Report Date : 03 FEB 1992

Pagination or Media Count : 27

Abstract : A synthesis laboratory has been established for the preparation of compounds to be evaluated against viruses of interest to U. S. Army Medical Research Institute of Infectious Diseases. The synthesis of known compounds as well as new compounds has been undertaken, and all compounds are being made in sufficient quantity to allow for full evaluation. The compounds prepared under this contract included nucleoside analogs and other heterocyclic compounds including 6-azauridine analogs, ribavirin analogs, and 1-substituted 4-acetyl-4-phenylpiperidines. Antiviral; synthesis laboratory; nucleoside analogs; heterocyclic compounds; 6-azauridine analogs; ribavirin analogs; 1-substituted 4-acetyl-4-phenylpiperidines.

Descriptors :   *HETEROCYCLIC COMPOUNDS, *NUCLEOSIDES, *ANTIVIRAL AGENTS, *SYNTHESIS(CHEMISTRY), ANALOGS, CONTRACTS, INFECTIOUS DISEASES, LABORATORIES, MEDICAL RESEARCH, PREPARATION, QUANTITY, VIRUSES, ARMY RESEARCH, CHEMICAL COMPOUNDS, PHARMACOLOGY, TEST AND EVALUATION.

Subject Categories : Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE