Accession Number : ADB165975

Title :   Turnover of Acetylcholine Receptors: Mechanisms of Regulation.

Descriptive Note : Final rept. 1 Aug 85-30 Nov 90,

Corporate Author : JOHNS HOPKINS UNIV BALTIMORE MD SCHOOL OF MEDICINE

Personal Author(s) : Drachman, Daniel B.

Report Date : 31 DEC 1990

Pagination or Media Count : 77

Abstract : The synthesis, insertion and degradation of acetylcholine receptors (AChRs) of skeletal muscle cells as closely regulated both by the muscle cells and by the motor nerves that supply them. The goal of this project is to elucidate the mechanisms of regulation of the AChRs, both at the neuromuscular junctional and at extrajunctional regions. The results of our studies on junctional AChRs have shown that: Both stable and rapidly turned over (RTO) AChRs are present at normally innervated neuromuscular junctions' Synthesis and insertion of AChRs at neuromuscular junctions occurs rapidly, at a rate consistent with the rapid rate of turnover of RTOs. RTOs serve as precursors of stable AChRs. Acetylcholine receptors, RA5 Neuromuscular junctions, Motor nerves.

Descriptors :   *ACETYLCHOLINE, *RECEPTOR SITES(PHYSIOLOGY), CELLS, DEGRADATION, JUNCTIONS, MOTORS, MUSCLES, NERVES, PRECURSORS, RATES, REGIONS, REGULATIONS, SUPPLIES, SYNTHESIS.

Subject Categories : Biology

Distribution Statement : APPROVED FOR PUBLIC RELEASE