Accession Number : ADB166046
Title : Research in Drug Development against Viral Diseases of Military Importance (Large-Scale Antiviral Drug Screening). Volume 1.
Descriptive Note : Final rept. 1 Feb-31 Dec 91,
Corporate Author : SOUTHERN RESEARCH INST BIRMINGHAM AL
Personal Author(s) : Shannon, W. M. ; Arnett, G. ; Brazier, A. D. ; Kirsi, J. J. ; Wilkoff, L. J.
Report Date : 31 DEC 1991
Pagination or Media Count : 365
Abstract : The purpose of this program was to evaluate the efficacy of candidate antiviral compounds against a spectrum of viruses of military importance. This program involved (a) prescreen vitro, (b) primary testing of synthetic compounds and active natural products in vitro against an expanded spectrum of viruses of military importance, (c) confirmatory testing of all active lead compounds from the prescreen and primary screen, (d) secondary in vitro and in vivo studies of selected active compounds with best broad spectrum antiviral activity. The target viruses for in vitro testing were Vaccinia Virus (VV), Yellow Fever Virus (YF), Japanese Encephalitis Virus (JE), Venezuelan Equine Encephalomyelitis Virus (VE), Punta Toro Virus (PT), Sandfly Fever Virus (SF) and Human Immunodeficiency Virus (HIV). The secondary in vitro and in vivo testing was carried out with three major classes of viruses (a)Filoviruses, (b) Arenaviruses and (c) Bunyaviruses. Approximately 5500 (2762 prescreen compounds and 2713 primary screen compounds) were received for in vitro evaluation and over 34,000 assays were performed on this contract. Compounds were identified in nearly all virus systems that have confirmed antiviral activity equal or exceeding that of the various positive control compounds (Ribavirin, Selenazofurin, Ara-A, ddC and AZT). Many of these compounds represent potent and selective new antiviral agents. Antiviral Drugs, In Vitro, HIV Exotic RNA Viruses, In Vivo, DNA Viruses, RA 1.
Descriptors : *HUMAN IMMUNODEFICIENCY VIRUSES, *YELLOW FEVER VIRUS, *VACCINIA VIRUS, ANTIVIRAL AGENTS, ARENAVIRUSES, CONTRACTS, CONTROL, DRUGS, ENCEPHALITIS, EQUINE ENCEPHALOMYELITIS VIRUS, EQUINES, FEVERS, HUMANS, JAPANESE ENCEPHALITIS, LEAD COMPOUNDS, SECONDARY, TARGETS, VENEZUELAN EQUINE ENCEPHALOMYELITIS, VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS, VIRUSES, YELLOW FEVER, IN VITRO ANALYSIS, IN VIVO ANALYSIS, SCREENS(DISPLAYS), MILITARY MEDICINE, RIBONUCLEIC ACIDS, DEOXYRIBONUCLEIC ACIDS.
Subject Categories : Microbiology
Distribution Statement : APPROVED FOR PUBLIC RELEASE