Accession Number : ADB167893
Title : Synthesis and Antiviral Evaluation of Pyrazofurin Analogues.
Descriptive Note : Annual rept. 19 Jun 91-18 Jun 92,
Corporate Author : UNIVERSITY OF SOUTH FLORIDA TAMPA
Personal Author(s) : Schneller, Stewart W.
Report Date : 19 JUL 1992
Pagination or Media Count : 48
Abstract : Synthetic methods have been investigated towards 5'-amino-5'deoxypyrazofurin, 5'-deoxy-5'-phosphonylpyrazofurin, 5'-deoxy-5'-phosphonylmethylpyrazofurin, a 5'-deoxy phosphoramidite pyrazofurin derivative, 3'-deoxy-3'-fluoropyrazofurin, and 5'-nor hydroxymethyl pyrazofurin. Preparation of the latter compound has been completed and this derivative will be submitted shortly for antiviral analysis. Antiviral data has been obtained for the N-methyl- and N,N-dimethylamide derivatives of pyrazofurin and for 5'-deoxypyrazofurin and 5'-homopyrazofurin. Only the N-methyl amide analogue showed any activity (versus influenza B only), which was insufficient to warrant further study. Pyrazofurin; Antiviral; Pyrazoles; Pyrroles; Ribofuranose derivatives; RA I.
Descriptors : *PYRAZOLES, *SYNTHESIS, AMIDES, INFLUENZA, PREPARATION, PYRROLES, TEST AND EVALUATION, TOXICITY, ANTIVIRAL AGENTS.
Subject Categories : Pharmacology
Distribution Statement : APPROVED FOR PUBLIC RELEASE