Accession Number : ADB167893

Title :   Synthesis and Antiviral Evaluation of Pyrazofurin Analogues.

Descriptive Note : Annual rept. 19 Jun 91-18 Jun 92,

Corporate Author : UNIVERSITY OF SOUTH FLORIDA TAMPA

Personal Author(s) : Schneller, Stewart W.

Report Date : 19 JUL 1992

Pagination or Media Count : 48

Abstract : Synthetic methods have been investigated towards 5'-amino-5'deoxypyrazofurin, 5'-deoxy-5'-phosphonylpyrazofurin, 5'-deoxy-5'-phosphonylmethylpyrazofurin, a 5'-deoxy phosphoramidite pyrazofurin derivative, 3'-deoxy-3'-fluoropyrazofurin, and 5'-nor hydroxymethyl pyrazofurin. Preparation of the latter compound has been completed and this derivative will be submitted shortly for antiviral analysis. Antiviral data has been obtained for the N-methyl- and N,N-dimethylamide derivatives of pyrazofurin and for 5'-deoxypyrazofurin and 5'-homopyrazofurin. Only the N-methyl amide analogue showed any activity (versus influenza B only), which was insufficient to warrant further study. Pyrazofurin; Antiviral; Pyrazoles; Pyrroles; Ribofuranose derivatives; RA I.

Descriptors :   *PYRAZOLES, *SYNTHESIS, AMIDES, INFLUENZA, PREPARATION, PYRROLES, TEST AND EVALUATION, TOXICITY, ANTIVIRAL AGENTS.

Subject Categories : Pharmacology
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE