Accession Number : ADB168632

Title :   Studies to Demonstrate the Feasibility of Producing a Powered Cold Sterilizing Agent.

Descriptive Note : Final rept. 15 Jan-15 Jul 91,

Corporate Author : RIDGECOM INC HAVERFORD PA

Personal Author(s) : Kramer, Shira

Report Date : 15 JUL 1991

Pagination or Media Count : 28

Abstract : The purpose of the research effort was to demonstrate the feasibility of producing a powdered quaternary ammonium-peroxide (QP) formulation (sometimes referred to as Ultra-Kleen ) for use at ambient temperature as a sterilizing agent for dental instruments. Microbiological efficacy tests were conducted to assess the efficacy of QP against B. subtilis, C sporogenes, and M. bovis. Kill curves at several use dilutions of QP were generated. In suspension, a 15% solution of QP exhibited sporicidal activity against both B. subtilis and C sporogenes, although some tailing was observed for C sporogenes. In these suspension tests, the D value for B. subtilis was 15.3 minutes, and for C sporogenes 67.9 minutes. A 15% solution of QP was tested, with an exposure time of two hours, against B. subtilis and C sporogenes dried on carriers, using the AOAC sporicidal test. Positive carriers were observed for both types of spores. The Quantitative Tuberculocidal Test (performed according to EPA guidelines) was performed using a 10% solution of QP. In this test the minimum required 99.9% reduction in organisms was achieved, with an exposure time claim calculated at 2 hours, 45 minutes. While the QP formulation tested established sporicidal activity, further work must concentrate on optimizing the technology to enhance penetration through dried medium on carriers. Sterilizing Agent, Cold Water, Powdered, Dental Instruments, Field Use, RAII, Disinfection, Sterilant, SBIR, Phase I.

Descriptors :   *COLD WATER, *STERILIZERS, DILUTION, DISINFECTION, FORMULATIONS, PENETRATION, PEROXIDES, PHASE, REDUCTION, SPORES, TEMPERATURE, TEST AND EVALUATION, TIME, VALUE, WATER, WORK, DENTAL EQUIPMENT, MEDICAL EQUIPMENT, QUATERNARY COMPOUNDS, AMMONIUM COMPOUNDS, PEROXIDES, POWDERS.

Subject Categories : Medical Facilities, Equipment and Supplies
      Medicine and Medical Research
      Hygiene and Sanitation

Distribution Statement : APPROVED FOR PUBLIC RELEASE