Accession Number : ADB170839

Title :   Preparation of Drugs and Bulk Chemical Compounds for the U.S. Army Drug Development Program.

Descriptive Note : Final rept. 15 Mar 89-30 Nov 92,

Corporate Author : ASH STEVENS INC DETROIT MI

Personal Author(s) : Blumbergs, P. ; Dagli, D. J. ; Dunkerton, L. V. ; Greening, D. A. ; Moore, J.

Report Date : 15 JAN 1993

Pagination or Media Count : 108

Abstract : The purpose of the program is to provide chemical compounds for the U.S. Army Medical R and D Command. In the 3.7 years, a total of 27 compounds were delivered in 31 lots. Of these, 26 were targets (30 lots) and one was an intermediate. The targets included five dialkyltetrasulfides, one bisquaternary dioxime, a phosphinylpentanoic acid, thiotaurine and the sodium salt, homothiotaurine, glutathione monoethyl ester, 8-chlorocaprylic acid, and fourteen 8-aminoquinolines. The 8-aminoquinolines included three potential metabolites of WR 238605 and four metabolate acetates as well as one metabolite and three metabolate acetates of WR 242511. 8-Aminoquinoline, Antimalarials, Metabolites, Dialkyltetrasulfide, Bisquaternary pyridinealdoxime, Thiotaurine, Glutathione, Phosphinylpentanoic acid, Synthesis.

Descriptors :   *SYNTHESIS(CHEMISTRY), *DRUGS, *BULK MATERIALS, ACETATES, ACIDS, ANTIMALARIALS, ARMY, CHEMICAL COMPOUNDS, CHEMICALS, ESTERS, GLUTATHIONE, METABOLITES, SALTS, SODIUM, SYNTHESIS, TARGETS, ARMY RESEARCH, MEDICAL SUPPLIES, PHARMACOLOGY.

Subject Categories : Pharmacology
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE