Accession Number : ADB171993

Title :   Feasibility of a Subunit Vaccine for Hepatitis A Virus: Studies on the Pathogenesis of Hepatitis A and Feasibility Studies on a Hepatitis A Vaccine.

Descriptive Note : Final rept. 23 May 88-31 Mar 92,

Corporate Author : UTAH UNIV SALT LAKE CITY SCHOOL OF MEDICINE

Personal Author(s) : Ehrenfeld, Elvera

Report Date : 01 MAY 1992

Pagination or Media Count : 25

Abstract : The overall goals of this contract are to explore the feasibility of the development of a subunit vaccine for hepatitis A virus (HAV). We have produced HAV structural proteins by recombinant DNA technology and characterized them as antigens for the induction of protective immunity. We have analyzed the replication strategies of HAV which contribute to its distinguishing growth properties and we have identified the HAV protein 3C as a viral protease. We have evaluated the human immune response to HAV infection. Hepatitis A virus, Subunit vaccine, RA I, Typhus, Virus, Vaccines, Biotechnology.

Descriptors :   *VACCINES, *PATHOGENESIS, *HEPATITIS VIRUSES, *FEASIBILITY STUDIES, ANTIGENS, BIOTECHNOLOGY, CONTRACTS, HUMANS, IMMUNITY, PEPTIDE HYDROLASES, PROTEINS, RESPONSE(BIOLOGY), STRATEGY, TYPHUS, DEOXYRIBONUCLEIC ACIDS, INFECTIOUS DISEASES, STRAINS(BIOLOGY), ANTIBODIES, CELLS(BIOLOGY), IMMUNE SERUMS, GENES.

Subject Categories : Medicine and Medical Research
      Pharmacology
      Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE