Accession Number : ADD000579

Title :   Determination of Methadone in Biological Specimens.

Descriptive Note : Patent,

Corporate Author : DEPARTMENT OF THE AIR FORCE WASHINGTON D C

Personal Author(s) : Hamilton,Horace E ; Wallace,Jack E

Report Date : 25 Mar 1975

Pagination or Media Count : 10

Abstract : This invention relates to a method for determining the presence of as well as the concentration of methadone in biological specimens. In one aspect it relates to a method of methadone determination that is particulary suitable for adaption to an automated analytical procedure. Methadone, in an aqueous solution in the presence of an alkane, can be readily oxidized to benzophenone by contacting it with ceric sulfate. By subjecting a solution of the benzophenone so obtained to spectrophotometric analysis, the absorbance of benzophenone is determined, thereby providing an indication of the amount of benzophenone, as well as the amount of methadone, that is present.

Descriptors :   *Patents, *Chemical analysis, Biological material, Spectrophotometry, Analgesics

Subject Categories : Medicine and Medical Research
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE