Accession Number : ADD000690

Title :   Stable Free-Radical Structures.

Descriptive Note : Patent Application,

Corporate Author : DEPARTMENT OF THE NAVY WASHINGTON D C

Personal Author(s) : Polis,Byrel D

Report Date : 03 Aug 1973

Pagination or Media Count : 10

Abstract : The patent application relates to a stable free-radical product, used to produce brain excitation in mammals when intravenously administered. The free-radical product is prepared from purified plasma proteins, pituitary peptides and other structures containing tyrosine or tryptophan by oxidation with a free-radical nitrosyl disulfonate product in alkaline solution under controlled conditions. Intravenous administration of the free-radical product into mammals causes a sudden electroencephalographic arousal accompanied by behavioral changes indicative of brain excitation. Illumination of the free-radical product by visible light prior to administration substantially enhances the arousal and brain excitation effects.

Descriptors :   *Free radicals, *CNS stimulants, Excitation, Proteins, Peptides, Tryptophan, Tyrosine, Patents, Synthesis(Chemistry), Sulfonates, Electroencephalography

Subject Categories : Biochemistry
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE