Accession Number : ADD003778

Title :   Benefication of Carbinolamine Compounds.

Descriptive Note : Patent Application,

Corporate Author : DEPARTMENT OF THE ARMY WASHINGTON D C

Personal Author(s) : Carroll,Frank I ; Olsen,Robert E

Report Date : 07 May 1976

Pagination or Media Count : 27

Abstract : This invention discloses a process for the conversion of erythro-alpha-(2-piperidyl)-2,8-bis-(trifluoromethyl)-4-quinoline methanol into the threo epimer. Said transformation results in practical means for obtaining an antimalarial having lower toxicity than the erythro compound, which is known as mefloquine. A relatively minor amount of the compound having the threo configuration is otherwise isolable from the manufacture of mefloquine.

Descriptors :   *Patent applications, *Antimalarials, *Quinolines, Isomerization, Stereochemistry, Piperidines, Fluorine compounds, Bioassay, Carbinols, Synthesis(Chemistry)

Subject Categories : Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE