Accession Number : ADD003778
Title : Benefication of Carbinolamine Compounds.
Descriptive Note : Patent Application,
Corporate Author : DEPARTMENT OF THE ARMY WASHINGTON D C
Personal Author(s) : Carroll,Frank I ; Olsen,Robert E
Report Date : 07 May 1976
Pagination or Media Count : 27
Abstract : This invention discloses a process for the conversion of erythro-alpha-(2-piperidyl)-2,8-bis-(trifluoromethyl)-4-quinoline methanol into the threo epimer. Said transformation results in practical means for obtaining an antimalarial having lower toxicity than the erythro compound, which is known as mefloquine. A relatively minor amount of the compound having the threo configuration is otherwise isolable from the manufacture of mefloquine.
Descriptors : *Patent applications, *Antimalarials, *Quinolines, Isomerization, Stereochemistry, Piperidines, Fluorine compounds, Bioassay, Carbinols, Synthesis(Chemistry)
Subject Categories : Organic Chemistry
Distribution Statement : APPROVED FOR PUBLIC RELEASE