Accession Number : ADD003781

Title :   Improved Process for Producing 8-NHR Quinolines.

Descriptive Note : Patent Application,

Corporate Author : DEPARTMENT OF THE ARMY WASHINGTON D C

Personal Author(s) : Chen,Eugene H ; Saggiamo,Andrew J ; Nodiff,Edward A

Report Date : 03 Mar 1977

Pagination or Media Count : 80

Abstract : An improved process for producing 8-NHR quinolines from 8-aminoquinolines is disclosed. The process comprises reacting 8-aminoquinolines with a substituted alkyl halide in the presence of an amine having a boiling point of 80-90 C. The amine functions as an acid acceptor whereby the amine salt formed may be efficiently separated from the 8-NHR quinoline formed without expensive or time consuming purification steps. The reaction may be carried out in the presence of a solvent such as an alcohol. (Author)

Descriptors :   *Patent applications, *Quinolines, *Antimalarials, Synthesis(Chemistry), Amines, Antiparasitic drugs, Halides, Alkyl radicals

Subject Categories : Pharmacology
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE