Accession Number : ADD004335

Title :   The Improvement of Plaque Dispersing Enzymes as Oral Therapeutic Agents by Molecular Alteration.

Descriptive Note : Patent Application,

Corporate Author : DEPARTMENT OF THE NAVY WASHINGTON D C

Personal Author(s) : Simonson,L G ; Lamberts,B C

Report Date : 03 Aug 1977

Pagination or Media Count : 16

Abstract : An oral therapeutic substance is formed by modifying a plaque-dispersing enzyme to control and reduce the occurrence of dental caries and periodontal diseases. In one embodiment, the modification is performed by introducing a suitable complexing reagent in combination with carrier and plaque-dispersing glucanohydrolase molecules to molecularly alter the glucanohydrolase. The modification, while having insignificant effects on the catalytic activity of the enzyme, will increase the binding capability of the enzyme to substances of which the tooth surface is formed. The activity of the enzyme on the tooth surface will therefore be maintained for longer periods of time to combat plaque build-up. (Author)

Descriptors :   *Patent applications, *Dental plaque, *Oral hygiene, *Enzymes, *Dental equipment, Oral bacteria, Streptococcus mutans, Stability, Therapy, Glucanase enzymes

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE