Accession Number : ADD007641

Title :   Anti-Leishmanial Lepidine Derivatives.

Descriptive Note : Patent,

Corporate Author : DEPARTMENT OF THE ARMY WASHINGTON DC

Personal Author(s) : Kinnamon,Kenneth E

Report Date : 24 Jun 1980

Pagination or Media Count : 9

Abstract : The subject 8-amino-6-methoxy lepidine derivatives have the formula: wherein, R represents an --alkylene (tertiary) amine, --alkylene-NH2, (N-alkylsubstituted piperadyl amino)-alkylene-, --alkylene-(tertiary) amine or -- alkylene-N-heterocyclic; R1, represents an alkoxy, alkyl, halogenated alkyl, alkenyl, aryloxy, halogen or hydrogen radical; R2 represents an alkyl, hologenated alkyl or aryloxy; n represents integers 3, 4, 5, 6 or 7; and pharmaceutically acceptable salts thereof wherein the salt forming acid or acid-hydrate is organic or inorganic. These derivatives afford improvement in means for the chemotherapy of leishmaniasis. Presence of a basic sidechain attachment at position 8-provides means for enhancement of the effectiveness of such compounds, which may be administered parenterally or orally to infected animals. (Author)

Descriptors :   *Patents, *Chemotherapeutic agents, Leishmaniasis, Chemotherapy, Preparation, Synthesis(Chemistry), Molecular structure, Hamsters, Dosage, Physiological effects

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE