Accession Number : ADD008397

Title :   Electromagnetic Method for the Noninvasive Analysis of Cell Membrane Physiological and Pharmacology.

Descriptive Note : Patent,


Personal Author(s) : Larsen,Lawrence E ; Jacobi,John H

Report Date : 16 Dec 1980

Pagination or Media Count : 31

Abstract : A method for electromagnetic analysis of cellular or cell ghost physiology and pharmacology without disrupting the physical integrity of the cell membrane is described. The method utilizes the technique of multifrequency automatic network analysis and signal processing to derive complex permittivities from the error corrected complex reflection coefficient of cell containing samples at each measured frequency. Complex permittivity at each frequency is then related to the dispersion in dielectric conductivity (a term which includes ohmic and non-ohmic losses) thereby measuring the ion permeability barrier and transport functions of the cell membrane and ion distribution inside of and outside of the cell membrane. The method measures the complex reflection coefficient of a capacitive termination containing a cellular sample as high frequencies are applied. Meaningful data can be developed in the range of frequencies of from 100 KHz to 100 MHz depending upon the exact nature of the cells and the automatic network analyzer used. (Author)

Descriptors :   *Patents, *Cells(Biology), *Membranes(Biology), Physiology, Pharmacology, Electromagnetic properties, Automatic, Signal processing, Frequency analyzers, Networks, Ions, Permeability, Distribution, Dielectric properties, Reflection, Coefficients

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE