Accession Number : ADD009416

Title :   Pharmacologically Active Amine Boranes.

Descriptive Note : Patent,

Corporate Author : DEPARTMENT OF THE ARMY WASHINGTON DC

Personal Author(s) : Spielvogel,Bernard F ; McPhail,Andrew T ; Hall,Iris H

Report Date : 26 Jan 1982

Pagination or Media Count : 7

Abstract : The use of amine boranes to inhibit the inflammation process is disclosed. These boranes, which are boron analogs of a-amino acids, effectively block the following: general inflammation, induced arthritis, and the writhing reflex associated with pleurisy is also inhibited. The boron analogs are shown in vitro to inhibit the release of lysosomal enzymes from liver and polymor-phonuclear neutrophils (PMNs). Further, prostaglandin synthesis is blocked by these compounds at a low concentration, viz, 10-6M. Liver oxidative phosphorylation processes are also uncoupled by these compounds, but PMN migration is unaltered at 10-4M.

Descriptors :   *Patents, *Boranes, *Amines, *Inhibitors, *Inflammation, Enzymes, In vitro analysis, Liver, Prostaglandin, Synthesis(Chemistry), Boron, Oxidation, Inventions, Phosphorylation

Subject Categories : Biochemistry
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE