Accession Number : ADD009729
Title : Prostaglandin Analogs and Process of Preparation Thereof.
Descriptive Note : Patent,
Corporate Author : DEPARTMENT OF THE NAVY WASHINGTON DC
Personal Author(s) : Nelson,George L
Report Date : 06 Jul 1982
Pagination or Media Count : 7
Abstract : Prostaglandin analogs and process for the preparation thereof as precursors for the synthesis of oligomeric mixtures exhibiting biological activity for protection of oxidative phosphorylation of degraded mitochondria. The analogs have the general formula: synthesized by O-alkylating a 2-alkylcycolopentane-1,3- dione to form an enot ether, reacting the ether with CH2=CHMgBr to form a vinyl, oxidizing the vinyl with OsO4 and NaIO4 to form an aldehyde, and reacting the aldehyde with a sodium salt of dimethyl (2-oxoalkyl)phosphonate.
Descriptors : *Patents, *Prostaglandin, *Analogs, *Synthesis(Chemistry), Enzyme precursors, Phosphorylation, Polymers, Mitochondria, Alkylation, Oxidation reduction reactions, Cyclopentanes, Ethers, Vinyl radicals, Aldehydes, Sodium compounds, Phosphonates, Reactants(Chemistry), Chemical derivatives
Subject Categories : Biochemistry
Distribution Statement : APPROVED FOR PUBLIC RELEASE