Accession Number : ADD010764

Title :   Treatment of Malaria with Liposomes Containing 8-Aminoquinoline Derivatives and Glycoconjugates.

Descriptive Note : Patent,

Corporate Author : DEPARTMENT OF THE ARMY WASHINGTON DC

Personal Author(s) : Alving,C R ; STeck,E A

Report Date : 22 Nov 1983

Pagination or Media Count : 13

Abstract : A novel treatment has been discovered for interrupting the life cycle of the malaria parasite during its development in the liver of the vertebrate host. The subject invention involves a method of chemotherapy against sporozoite-induced malaria by administering an 8-aminoquinoline drug, such as primaquine, encapsulated within liposomes containing glycoconjugates, to a vertebrate host which has been infected with sporozoites of the parasites. Preferred species of glycoconjugates have a terminal glucose or galactose moiety, such as present in glycosyl ceramide, galactosyl ceramide, lactosyl ceramide, or in glycoproteins. (Author)

Descriptors :   *Patents, *Antimalarials, *Quinolines, Malaria, Amines, Chemotherapy, Sporozoites, Primaquine

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE