Accession Number : ADD011343

Title :   4-Methyl-5-(Unsubstituted and Substituted Phenoxy)-6-Methoxy-8-(Aminoalkylamino)Quinolines.

Descriptive Note : Patent,

Corporate Author : DEPARTMENT OF THE ARMY WASHINGTON DC

Personal Author(s) : Strube,R E ; LaMontagne,M P

Report Date : 14 Feb 1984

Pagination or Media Count : 16

Abstract : Compounds of the class including 4-methyl-5-(unsubstituted and substituted phenoxy)-6-methoxy-8-(aminoalkylamino)quinolines as the free bases and pharmaceutically acceptable acid amine salts are described. The compounds are highly effective antimalarial agents which posses, surprisingly, both tissue schizonticidal (radical curative) and blood schizonticidal (suppressive) activity. In addition, these drugs have significantly better therapeutics indices than primaquine which is the current tissue schizonticidal drug of choice. Primaquine possesses no useful blood schizonticidal activity at tolerated dose levels.

Descriptors :   *Patents, *Antimalarials, *Quinolines, Chemical analogs, Molecular structure, Dosage, Physiological effects, Test methods

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE