Accession Number : ADD011343
Title : 4-Methyl-5-(Unsubstituted and Substituted Phenoxy)-6-Methoxy-8-(Aminoalkylamino)Quinolines.
Descriptive Note : Patent,
Corporate Author : DEPARTMENT OF THE ARMY WASHINGTON DC
Personal Author(s) : Strube,R E ; LaMontagne,M P
Report Date : 14 Feb 1984
Pagination or Media Count : 16
Abstract : Compounds of the class including 4-methyl-5-(unsubstituted and substituted phenoxy)-6-methoxy-8-(aminoalkylamino)quinolines as the free bases and pharmaceutically acceptable acid amine salts are described. The compounds are highly effective antimalarial agents which posses, surprisingly, both tissue schizonticidal (radical curative) and blood schizonticidal (suppressive) activity. In addition, these drugs have significantly better therapeutics indices than primaquine which is the current tissue schizonticidal drug of choice. Primaquine possesses no useful blood schizonticidal activity at tolerated dose levels.
Descriptors : *Patents, *Antimalarials, *Quinolines, Chemical analogs, Molecular structure, Dosage, Physiological effects, Test methods
Subject Categories : Pharmacology
Distribution Statement : APPROVED FOR PUBLIC RELEASE