Accession Number : ADD011352

Title :   Intramolecularly Crosslinked Hemoglobin.

Descriptive Note : Patent,

Corporate Author : DEPARTMENT OF THE ARMY WASHINGTON DC

Personal Author(s) : Scannon,P J

Report Date : 25 Sep 1984

Pagination or Media Count : 3

Abstract : This invention relates to molecular modification of hemoglobin by utilization of a class of a, omega-dialdelhydes having a chain length of 5 to 7 members and substituted with at least one negatively charged group such as a phosphate moiety. A subject a, omega-dialdehyde can be synthesized by sodium periodate oxidation of a phosphorylated ribose such as adenosine-5'-triphosphate or 5-phosphoribosyl-1-pyrophosphate. The compounds of this invention can be advantageously used for intramolecularly crosslinking hemoglobin for resuscitative purposes.

Descriptors :   *Patents, *Hemoglobin, Molecules, Crosslinking(Chemistry), Modification

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE