Accession Number : ADD011686

Title :   Magnetically-Localizable, Polymerized Lipid Vesticles and Method of Disrupting Same.

Descriptive Note : Patent Application,

Corporate Author : DEPARTMENT OF THE NAVY WASHINGTON DC

Personal Author(s) : Chang,E L

Report Date : 12 Mar 1985

Pagination or Media Count : 16

Abstract : It is an object of this invention to provide lipid vesicles that are stable in vivo to unintended physical and chemical disruption. A further object of this invention is to provided vesicles with polymerizable membranes. A further object of this invention is to provide vesicles that can carry aqueous solutions of therapeutic agents. A further object of this invention is to provide vesicles that can be immoblized at an in vivo target site by an external magnetic field. A further object of this invention is to control the rate of release of an encapulated therapeutic agent at the target site by oscillating the magnetic field. These and other objects are achieved by encapsulating therapeutic agents and ferromagnetic particles in a lipid vesicle formed using polymerizable lipids whichare subsequently polymerized to form a stable vesicle resistant to chemical and physical attack. The vesicles are attracted to the targeted site by an external magnetic field. Once localized at the target site, an oscillating magnetic field is used to destabilize the vesicle membrane resulting in controlled release of the therapeutic agent at the target site. This is a patent application.

Descriptors :   *PATENT APPLICATIONS, *CAVITIES, *LIPIDS, *CAPSULES(PHARMACY), ATTACK, CAVITIES, CHEMOTHERAPEUTIC AGENTS, EXTERNAL, FERROMAGNETIC MATERIALS, IN VIVO ANALYSIS, INVENTIONS, LIPIDS, MAGNETIC FIELDS, OSCILLATION, PARTICLES, PHYSICAL PROPERTIES, POLYMERIZATION, RATES, RELEASE, SITES, SOLUTIONS(MIXTURES), STABILITY, CHEMICAL ATTACK(DEGRADATION), RESISTANCE

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE