Accession Number : ADD012484

Title :   Scaled-Up Production of Liposome-Encapsulated Hemoglobin.

Descriptive Note : Patent Application,

Corporate Author : DEPARTMENT OF THE NAVY WASHINGTON DC

Personal Author(s) : Farmer,Martha C ; Beissinger,Richard L

Report Date : 29 Aug 1986

Pagination or Media Count : 34

Abstract : This invention relates to blood substitutes, and methods for their preparation. More particularly, it relates to a novel composition which can be administered to human patients as a blood substitute by transfusion. A method for making sterile liposome-encapsulated hemoglobin having an oxygen carrying capacity of 20 vol/%, a half life of 15-20 hours as measured in mice, with the liposome made from chloroform, HSPC, cholesterol, negatively charged DMPG and alpha-tocopherol is disclosed.

Descriptors :   *PATENT APPLICATIONS, *BLOOD SUBSTITUTES, *HEMOGLOBIN, BLOOD TRANSFUSION, CHLOROFORM, CHOLESTEROL, CYTOPLASM, HALF LIFE, HUMANS, MICE, OXYGEN, PATIENTS, PRODUCTION, SCALING FACTORS, LIPIDS, ENCAPSULATION, STERILIZATION

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE