Accession Number : ADD012484
Title : Scaled-Up Production of Liposome-Encapsulated Hemoglobin.
Descriptive Note : Patent Application,
Corporate Author : DEPARTMENT OF THE NAVY WASHINGTON DC
Personal Author(s) : Farmer,Martha C ; Beissinger,Richard L
Report Date : 29 Aug 1986
Pagination or Media Count : 34
Abstract : This invention relates to blood substitutes, and methods for their preparation. More particularly, it relates to a novel composition which can be administered to human patients as a blood substitute by transfusion. A method for making sterile liposome-encapsulated hemoglobin having an oxygen carrying capacity of 20 vol/%, a half life of 15-20 hours as measured in mice, with the liposome made from chloroform, HSPC, cholesterol, negatively charged DMPG and alpha-tocopherol is disclosed.
Descriptors : *PATENT APPLICATIONS, *BLOOD SUBSTITUTES, *HEMOGLOBIN, BLOOD TRANSFUSION, CHLOROFORM, CHOLESTEROL, CYTOPLASM, HALF LIFE, HUMANS, MICE, OXYGEN, PATIENTS, PRODUCTION, SCALING FACTORS, LIPIDS, ENCAPSULATION, STERILIZATION
Subject Categories : Pharmacology
Distribution Statement : APPROVED FOR PUBLIC RELEASE