Accession Number : ADD012590

Title :   Phospholipid Compositions and Their Effective Use as Anti-Tumor Agents.

Descriptive Note : Patent Application,

Corporate Author : DEPARTMENT OF THE ARMY WASHINGTON DC

Personal Author(s) : Jett-Tilton,Marti ; Alving,Carl R

Report Date : 25 Sep 1986

Pagination or Media Count : 42

Abstract : This patent application discloses a composition and method for killing tumor cells with phospholipids, or mixtures of appropriate lipids, as drugs. These drugs have been shown to have marked effectiveness in inhibiting the growth of tumor cells and are, therefore, useful as anti-tumor agents. Phospholipids having appropriate unsaturated fatty acids in the sn-2 position of the phosphatidylinositol or phosphatidylcholine were effective. Fatty acids having less than two double bonds (e.g., or oleic acid) were less effective, and saturated fatty acids (e.g., stearic acid) were ineffective. Plant PI that was previously used contained lineoleic acid (having 2 double bonds) in the sn-2 position. The present invention provides a broad and unexpected pattern of phospholipid cytotoxic activity that would embrace plant PI as well as other phospholipids with sn-2 unsaturated fatty acids.

Descriptors :   *PATENT APPLICATIONS, *CHEMOTHERAPEUTIC AGENTS, *NEOPLASMS, CELLS(BIOLOGY), CELL DIVISION, OLEIC ACID, STEARIC ACID, FATTY ACIDS, LIPIDS, CYTOTOXIN, SATURATION, NEOPLASMS, UNSATURATED HYDROCARBONS

Subject Categories : Biochemistry
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE